pentose phosphate pathway

pentose phosphate pathway
(= pentose shunt; hexose monophosphate pathway; phosphogluconate oxidative pathway)
Alternative metabolic route to Embden-Meyerhof pathway for breakdown of glucose. Diverges from this when glucose-6-phosphate is oxidized to ribose 5-phosphate by the enzyme glucose-6-phosphate dehydrogenase. This step reduces NADPto NADPH, generating a source of reducing power in cells for use in reductive biosyntheses. In plants, part of the pathway functions in the formation of hexoses from CO2 in photosynthesis. Also important as source of pentoses, eg. for nucleic acid biosynthesis. This pathway is the main metabolic pathway in neutrophil leucocytes; congenital deficiency in the pathway produces sensitivity to infection.

Dictionary of molecular biology. 2004.

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  • Pentose phosphate pathway — The pentose phosphate pathway (also called Phosphogluconate Pathway, or HexoseMonophosphate Shunt [HMP shunt] ) is a process that serves to generate NADPH and the synthesis of pentose (5 carbon) sugars. There are two distinct phases in the… …   Wikipedia

  • pentose phosphate pathway — a major branching of the Embden Meyerhof pathway of carbohydrate metabolism: a pathway of hexose oxidation in which glucose 6 phosphate undergoes two successive oxidations by NADP, the final one being an oxidative decarboxylation to form a… …   Medical dictionary

  • pentose phosphate pathway — (pen tōs) The pathway that oxidizes glucose 6 phosphate to ribulose 5 phosphate and then converts it to a variety of three to seven carbon sugars; it forms several important products (NADPH for biosynthesis, pentoses, and other sugars) and also… …   Dictionary of microbiology

  • pentose phosphate pathway — noun an alternative series of biochemical reactions to glycolysis for oxidising glucose, important for the synthesis of pentoses …  

  • pentose shunt — pentose phosphate pathway …   Medical dictionary

  • Pentose — A pentose is a monosaccharide with five carbon atoms.They either have an aldehyde functional group in position 1 (aldopentoses), or a ketone functional group in position 2 (ketopentoses).The aldopentoses have three chiral centres ( asymmetric… …   Wikipedia

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  • Glucose-6-phosphate — Chembox new ImageFileL1=Glucose 6 phosphate skeletal.png ImageFileR1=Beta D glucose 6 phosphate 3D balls.png ImageSize= IUPACName=(3,4,5,6 tetrahydroxytetrahydropyran 2 yl) methoxyphosphonic acid OtherNames= Section1= Chembox Identifiers CASNo=56 …   Wikipedia

  • Metabolic pathway — In biochemistry, metabolic pathways are series of chemical reactions occurring within a cell. In each pathway, a principal chemical is modified by a series of chemical reactions. Enzymes catalyze these reactions, and often require dietary… …   Wikipedia

  • Ribose 5-phosphate — IUPAC name (2,3,4 Trihydroxy 5 oxo pentoxy)phosphonic acid …   Wikipedia

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